03233nam a2200361Ii 4500 CRC0KE23124PDF FlBoTFG 20171224123216.0 m|||||o||d|||||||| cr|||| 130918s2014 fluadf ob 001 0 eng d 9781466588127 (ebook : PDF) FlBoTFG eng FlBoTFG rda RC904 .K53 2014 616.61075 K467 Kidney : toxicological assessment / editor, Sang Geon Kim, Professor of Pharmacology, College of Pharmacy, Seoul National University, Seoul, South Korea. Boca Raton, Fla. : Taylor & Francis, [2014] 1 online resource : text file, PDF text rdacontent computer rdamedia online resource rdacarrier Includes bibliographical references and index. 1. Cellular organelle-based renal toxicity / Young-Jin Chun -- 2. Transcriptomic approaches to toxicity assessment / Dal Woong Choi, Woonun Jung, Il Je Cho, Min Sung Joo, Chan Gyu Lee, Sang Woo Lim, and Sang Geon Kim -- 3. Proteomic approaches to toxicity assessment / Sun Young Kim, So Jung Son, and Aree Moon -- 4. A metabolomics approach for evaluation of target-organ toxicity / Kyu-Bong Kim, A Jin Won, Suhkmann Kim, Byung Mu Lee, and Hyung Sik Kim -- 5. In silico approaches to study drug-induced renal toxicity / Rajiv Gandhi Govindaraj, Prasannavenkatesh Durai, and Sangdun Choi -- 6. Systems toxicology approaches / Hyobin Jeong, Sang Chul Rho, and Daehee Hwang -- 7. Introduction to virtual cell and its possible application to toxicity / Ji-Young Hong, Eun Bo Shim, and Kwang Hyun Cho -- 8. Molecular pathology of renal fibrosis / Inah Hwang, Joo young Huh, and Hunjoo Ha -- 9. Clinical implications of renal toxicity / Duk-Hee Kang -- 10. Classification of nephrotoxicants / Hang-Sik Roh, Jong-Kwon Lee, Tae-Sung Kim, Ji-Hyeon Seok, Ji-Hyun Yun,Ji-Young Yun, Saet-Byul Oh, Soon-Young Han and Jayoung Jeong. "This book bridges the gap between advances in basic biology and chemistry and technological applications in the field of toxicity assessments. 10 chapters describe major areas of progress in the laboratory and clinic. In the first section, the aspects of cellular organelles are discussed. In the second, the basic principles and applications of modern toxicological tools such as transcriptomic, proteomic, and metabolomic approaches are covered. In the third section, the recent developments on molecular modeling and systems biology are described with an eye on the future establishment of virtual cell technology. Finally the clinical implications for the understanding of acute and chronic renal toxicity are studied"--Provided by publisher. Also available in print format. Kidneys Diseases. Renal pharmacology. Toxicity testing. Electronic books. lcsh Kim, Sang Geon, editor of compilation. Print version: 9781466588110 (hardback : alk. paper) http://marc.crcnetbase.com/isbn/9781466588127 application/PDF Distributed by publisher. Purchase or institutional license may be required for access. 14436 14436